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GALLBLADDER

Gallbladder Surgery (Cholecystectomy) in Uberlândia, Brazil

Removal of the gallbladder with stones by laparoscopy or robotic surgery — the most frequent operation in digestive tract surgery, explained with the numbers from the literature.

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Dr. Solon Gonçalves Souza Menezes, digestive system and robotic surgeon in Uberlândia, Brazil

Dr. Solon Gonçalves Souza Menezes

CRM-MG 79366 · RQE 60355 (Digestive System Surgery) · RQE 44656 (General Surgery)

Professor of Surgery — FAMED UFU · Robotic Surgery Certification (Intuitive / Albert Einstein Hospital) · Practices at Hospital UMC and Hospital Mater Dei Santa Genoveva, Uberlândia, Brazil · +55 (34) 99341-0915

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The gallbladder is a small pouch under the liver that stores bile and releases it into the intestine during meals. When bile becomes too concentrated, stones form — gallstones. They are very common: according to the 2016 European guideline (EASL), 10% to 20% of Western populations have gallstones, and about 80% of those people never feel anything. Among those with silent stones, only 1% to 4% per year develop symptoms, almost always biliary colic: severe pain in the upper abdomen, usually after a fatty meal, which may radiate to the back or the right shoulder and last a few hours.

The decision to operate depends, first of all, on whether there are symptoms. For stones with symptoms, cholecystectomy (removal of the gallbladder) is the option preferred by the guidelines, with a strong recommendation: after the first colic, about half of patients have further attacks, and the annual risk of complications — acute cholecystitis (inflammation of the gallbladder), pancreatitis, jaundice from a stone in the bile duct — rises to 1% to 3% per year. Stones without symptoms should not be operated on routinely, because the risk of complications is low (0.1% to 0.3% per year) and does not outweigh the risk of an operation. There are exceptions, assessed case by case at the consultation.

Illustration of the gallbladder with stones, under the liver, with the bile ducts and its location in the body
Didactic illustrationThe gallbladder sits under the liver and stores bile, which reaches the duodenum through the bile ducts. When bile becomes too concentrated, stones form inside the gallbladder — cholelithiasis. In a cholecystectomy the whole gallbladder is removed together with the stones, by laparoscopy or robotics; the liver keeps producing bile normally.

The reference operation is laparoscopic cholecystectomy: more than 93% of cholecystectomies worldwide already start this way, and the European guideline considers it the standard, with high-quality evidence, including in acute cholecystitis. Under general anesthesia, through three or four small incisions, the surgeon safely identifies the cystic duct and the cystic artery — the critical view of safety, the central principle of the 2020 multi-society guideline for preventing bile duct injury —, closes both with clips and removes the gallbladder with the stones through the umbilical incision. The common bile duct, which carries bile from the liver to the intestine, is preserved. Conversion to open surgery occurs in 4% to 8% of cases, more often in severely inflamed gallbladders.

Dr. Solon Gonçalves performs cholecystectomy by both minimally invasive routes — laparoscopic and robotic, at Hospital UMC and Hospital Mater Dei Santa Genoveva in Uberlândia, Brazil. The robotic platform offers magnified three-dimensional vision and articulated instruments, but it is important to be transparent about what the literature shows for the gallbladder: the most recent meta-analyses do not demonstrate a clinical advantage of robotics over laparoscopy, which remains the standard of care; time and cost are higher, and a large North American registry study found more bile duct injuries with robotics, a finding that may reflect the learning curve. For this reason, the robotic route is reserved for selected cases, decided together with the patient. One frequent question at the clinic: gallbladder surgery is not “laser” surgery — the popular expression actually refers to laparoscopy.

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WHEN TO OPERATE

Who has an indication for gallbladder surgery.

The indication follows the international guidelines (EASL 2016, WSES 2020 and Tokyo 2018) and is always confirmed at the individual assessment, with physical examination, ultrasound and blood tests.

01

Stones with symptoms

Typical biliary colic, even if it has happened only once: cholecystectomy is the preferred approach, and the guidelines advise operating as early as possible. In one clinical trial, 22.5% of patients kept on a waiting list (average of 4 months) had serious events — pancreatitis, empyema, cholangitis — while they waited.

02

Acute cholecystitis (inflamed gallbladder)

Continuous pain, fever and an inflamed gallbladder on examination: early surgery, ideally within 72 hours of admission and at most within 7 days (or 10 days from the onset of symptoms), is the recommended approach when the patient's condition allows. Operating between the 2nd and the 6th week increases morbidity; if the window has passed, surgery is scheduled after about 6 weeks.

03

Complications of the stones

Biliary pancreatitis, jaundice or cholangitis caused by a stone that has migrated into the common bile duct: treatment combines removal of the stone from the bile duct (usually by endoscopy) and cholecystectomy, to prevent new episodes.

04

Stones without symptoms

Not operated on routinely: the risk of complications is 0.1% to 0.3% per year. Specific situations — such as suspicious imaging findings or conditions that raise the risk — are discussed individually at the consultation.

HOW IT IS DONE

Laparoscopy and robotics: what the evidence shows for the gallbladder.

Both routes remove the gallbladder through the same small incisions and follow the same safety principles. The difference is the platform: in laparoscopy the surgeon handles the instruments directly; in robotics, articulated instruments with 3D vision are controlled from a console. The table summarizes the comparative data published up to 2026.

AspectLaparoscopyRobotic surgery
Incisions3 to 4 incisions of 0.5 to 1.2 cm3 to 4 incisions of similar size
Vision and instrumentsHigh-definition image; straight instrumentsMagnified three-dimensional vision; articulated instruments
Conversion to open surgery4% to 8% (EASL 2016); higher in acute cholecystitisLower in meta-analyses of observational studies (OR 0.44)
Bile duct injuryReported between 0.04% and 1.5%; major injury around 0.2% to 0.4%No evidence of reduction; a North American registry (Medicare) found 0.7% vs 0.2% of injuries requiring reconstruction
Operative timeGenerally shorterLonger in meta-analyses (e.g. 75 vs 60 min)
Hospital stayDischarge the same day or the next daySimilar
CostLower2 to 3 times higher
Current roleStandard of care for most patientsOption in selected cases, decided case by case

On a phone, drag the table sideways to see all the columns.

Sources: EASL 2016; Kalata et al., JAMA Surg 2023; Coco & Leanza, J Robot Surg 2026; Delpino et al., Am J Surg 2026. Most comparative data come from observational studies, subject to selection bias — none of these differences can be promised to an individual patient.
PREPARATION AND RECOVERY

What to expect before and after surgery.

Preoperative preparation

Before surgery, blood tests, ultrasound (sometimes magnetic resonance of the bile ducts, when a stone in the common bile duct is suspected) and an anesthetic assessment are requested. Fasting follows the hospital protocol; anticoagulants and some other medications are temporarily suspended under medical guidance, and smoking should stop. Patients using GLP-1 medications for weight loss or diabetes (such as semaglutide and tirzepatide) must inform the team: they slow gastric emptying and may require an adjustment of the fasting period or of the anesthetic technique. In acute cholecystitis, preparation is done during the admission and surgery takes place in the first days.

Recovery and postoperative care

Most patients are discharged the same day or the next morning — a Cochrane review showed that same-day discharge is as safe as an overnight stay, although about 20% of patients end up needing to stay. Mild pain at the incisions is common and, in the first days, so is referred shoulder pain from the gas used during surgery. Food is reintroduced lightly and progressively. Daily activities are usually resumed within a few days; work without physical effort, in 1 to 2 weeks; effort and lifting, generally after 4 weeks. Convalescence is about 3 weeks shorter than after open surgery. Any fever, jaundice (yellow skin) or intense pain must be reported immediately.

RISKS AND COMPLICATIONS

The risks of cholecystectomy, with the published numbers.

Laparoscopic cholecystectomy is a safe and highly standardized operation, but no surgery carries zero risk. The numbers below come from registries and series compiled by the European guideline (EASL 2016) and the World Society of Emergency Surgery (WSES 2020) and serve as a reference, not as an individual guarantee.

  • Bile duct injury — the most feared serious complication. In laparoscopic cholecystectomy it is reported between 0.04% and 1.5% (any grade); major injuries, with transection of the duct, are around 0.2% to 0.4% (0.3% in more than 50,000 patients of the Swedish registry). The guideline itself acknowledges that the true incidence may be under-reported. When identified, treatment must be carried out by an experienced hepatobiliary team.
  • Bile leak — 0.4% to 1.5%; usually treated with drainage and, at times, endoscopy.
  • Bleeding — 0.2% to 1.4%; wound infection — 1.3% to 1.8%; pancreatitis — about 0.3%.
  • Conversion to open surgery — 4% to 8% overall, up to about 20% in acute cholecystitis; it is not a complication but a safety decision.
  • Acute cholecystitis — the higher-risk scenario: mortality of 0.1% to 1%, bile duct injury of 0.2% to 1.5% and major complications (cardiac, pulmonary, thromboembolic) in 6% to 9% of cases, according to WSES 2020.
  • Retained stone in the bile duct — may show up after surgery, with pain or jaundice, and is generally resolved by endoscopy (ERCP).
  • General risks — anesthesia, venous thrombosis, hernia at the incisions and infection, with low frequencies that are reduced by perioperative care.
FREQUENTLY ASKED QUESTIONS

Common questions about this procedure.

Do gallstones always need surgery?+

No. Those who have stones and have never had symptoms do not need routine surgery, because the risk of complications is low (0.1% to 0.3% per year). Those who have had biliary colic should be operated on, preferably soon: half of patients have further attacks and the risk of complications rises to 1% to 3% per year. This is the position of the European guideline (EASL 2016).

What happens if I do not remove my gallstones?+

If there are no symptoms, probably nothing: about 80% of people with stones never feel anything, and only 1% to 4% per year develop symptoms. If there has already been colic, the scenario changes — the chance of new attacks and of complications such as acute cholecystitis, pancreatitis and bile duct obstruction is higher, and these complications are what make surgery more difficult and riskier.

Can gallstones pass on their own or dissolve with medication or tea?+

Gallstones do not disappear with teas or diets. Dissolution with medication has a very restricted indication, does not work for most cases and the stones tend to return. Small stones can migrate into the bile duct — and that, instead of solving the problem, causes pancreatitis or jaundice. For symptomatic stones, the reference approach remains removal of the gallbladder.

Is gallbladder surgery dangerous?+

It is one of the most frequently performed and standardized operations in the world, with very low mortality in the elective setting. The risks exist and are described on this page: bile duct injury (major injury in about 0.2% to 0.4%), bile leak, bleeding and infection, all infrequent. The risk is higher when the gallbladder is severely inflamed — one more reason not to postpone surgery after the first attack.

Is gallbladder surgery done with a laser?+

There is no laser gallbladder surgery. The popular expression refers to laparoscopy, done through small incisions with a camera. Lasers play no role in removing the gallbladder.

Laparoscopy or robotics: which is better for the gallbladder?+

For the gallbladder, laparoscopy remains the standard: the most recent meta-analyses show no clinical benefit from robotics, which takes longer and costs more, and a large North American registry found more bile duct injuries with the robot. Dr. Solon performs both techniques and reserves robotics for selected cases — for example, when another operation is performed at the same time. The choice is made together, at the consultation.

What is the anesthesia like, how long does it take and how many incisions are made?+

Cholecystectomy is performed under general anesthesia, through three or four small incisions (0.5 to 1.2 cm). Surgery usually takes around one hour and may be longer when the gallbladder is severely inflamed or there are adhesions from previous operations.

How long is the hospital stay, the rest period and the sick leave?+

Discharge usually happens the same day or the next morning. Light activities are resumed in a few days; work without physical effort, in 1 to 2 weeks; physical effort and lifting, generally after 4 weeks. Sick leave is defined individually according to the occupation and each patient's recovery.

What changes after the gallbladder is removed? What can't I eat?+

Bile is still produced by the liver and reaches the intestine normally — the difference is that there is no longer a reservoir. In the first weeks, smaller meals with less fat are usually better tolerated, and some people notice softer stools, which tend to normalize. There is no mandatory permanent diet: the vast majority return to their usual eating habits.

Do weight-loss injections (Ozempic, Mounjaro) increase the risk of gallstones?+

Yes. A meta-analysis of 76 randomized clinical trials, with more than 100,000 participants, published in JAMA Internal Medicine in 2022, showed that GLP-1 medications increase the risk of gallbladder and biliary diseases (relative risk 1.37), and in weight-loss trials that risk more than doubled (relative risk 2.29), especially with high doses and prolonged use. This does not contraindicate the treatment, which is prescribed and monitored by the attending physician — but anyone losing weight with these medications who feels abdominal pain should be assessed.

Can gallstones turn into cancer?+

Gallstones are a known risk factor for gallbladder cancer, but this cancer is rare and the individual risk of someone with stones is very low — which is why the presence of stones alone is not a reason to operate on someone without symptoms. Changes in the gallbladder wall seen on imaging are what demand attention, and they are assessed case by case. Learn more on the gallbladder cancer page.

Inflamed gallbladder: is it better to operate right away or wait for the inflammation to settle?+

Operate right away. The guidelines recommend early surgery in acute cholecystitis — within 72 hours of admission, according to EASL, or within 7 days (and 10 days from the onset of symptoms), according to WSES. A Cochrane review showed that early surgery shortens the total hospital stay by about 4 days, and that 18% of patients who waited needed emergency surgery before the scheduled date. When the initial window has passed, surgery is delayed around 6 weeks, because operating between the 2nd and the 6th week increases morbidity.

Do you operate through the SUS, the Brazilian public health system?+

I do operate through the SUS. I am a Professor of Surgery at the School of Medicine of the Federal University of Uberlândia and I operate on patients at the university hospital, HC-UFU. The route, however, does not go through my private practice: to be operated on through the SUS you must go to the health post or Basic Health Unit nearest your home, be assessed by a doctor and, if surgery is indicated, be placed in your municipality's regulation queue. The surgeon does not choose who gets operated on through the SUS — the queue is followed strictly, according to SUS rules.

WHERE WE OPERATE

Hospital facilities in Uberlândia, Brazil.

Hospital Mater Dei Santa Genoveva

Av. Vasconcelos Costa, 967 — Martins, Uberlândia-MG

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Hospital UMC

Rua Rafael Marino Neto, 600 — Jardim Karaíba, Uberlândia-MG

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Content reviewed by Dr. Solon Gonçalves Souza Menezes — CRM-MG 79366, RQE 60355 (GI Surgery), RQE 44656 (General Surgery). Professor of Surgery at FAMED-UFU and Supervisor of the General Surgery Medical Residency Program at HC-UFU. ORCID. Last reviewed: October/2026.

References
  1. European Association for the Study of the Liver (EASL). EASL Clinical Practice Guidelines on the prevention, diagnosis and treatment of gallstones. J Hepatol. 2016;65(1):146-181. doi:10.1016/j.jhep.2016.03.005
  2. Pisano M, Allievi N, Gurusamy K, et al. 2020 World Society of Emergency Surgery updated guidelines for the diagnosis and treatment of acute calculus cholecystitis. World J Emerg Surg. 2020;15(1):61. doi:10.1186/s13017-020-00336-x
  3. Okamoto K, Suzuki K, Takada T, et al. Tokyo Guidelines 2018: flowchart for the management of acute cholecystitis. J Hepatobiliary Pancreat Sci. 2018;25(1):55-72. doi:10.1002/jhbp.516
  4. Gurusamy KS, Davidson C, Gluud C, et al. Early versus delayed laparoscopic cholecystectomy for people with acute cholecystitis. Cochrane Database Syst Rev. 2013;(6):CD005440. doi:10.1002/14651858.CD005440.pub3
  5. Gurusamy KS, Koti R, Fusai G, et al. Early versus delayed laparoscopic cholecystectomy for uncomplicated biliary colic. Cochrane Database Syst Rev. 2013;2013(6):CD007196. doi:10.1002/14651858.CD007196.pub3
  6. Vaughan J, Gurusamy KS, Davidson BR. Day-surgery versus overnight stay surgery for laparoscopic cholecystectomy. Cochrane Database Syst Rev. 2013;2013(7):CD006798. doi:10.1002/14651858.CD006798.pub4
  7. Brunt LM, Deziel DJ, Telem DA, et al. Safe Cholecystectomy Multi-society Practice Guideline and State of the Art Consensus Conference on Prevention of Bile Duct Injury During Cholecystectomy. Ann Surg. 2020;272(1):3-23. doi:10.1097/SLA.0000000000003791
  8. Kalata S, Thumma JR, Norton EC, et al. Comparative Safety of Robotic-Assisted vs Laparoscopic Cholecystectomy. JAMA Surg. 2023;158(12):1303-1310. doi:10.1001/jamasurg.2023.4389
  9. Coco D, Leanza S. Comparative effectiveness, safety, and cost of laparoscopic versus robotic minimally invasive cholecystectomy: a systematic review and meta-analysis. J Robot Surg. 2026;20(1):177. doi:10.1007/s11701-025-02863-8
  10. Delpino FM, Tustumi F, Siqueira MM, et al. Comparison between open, laparoscopic, and robotic cholecystectomy: a systematic review and meta-analysis. Am J Surg. 2026;257:116972. doi:10.1016/j.amjsurg.2026.116972
  11. He L, Wang J, Ping F, et al. Association of Glucagon-Like Peptide-1 Receptor Agonist Use With Risk of Gallbladder and Biliary Diseases: A Systematic Review and Meta-analysis of Randomized Clinical Trials. JAMA Intern Med. 2022;182(5):513-519. doi:10.1001/jamainternmed.2022.0338